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Download Bio Dr. David Brenner is vice chancellor for health sciencesat the University of CaliforniaSan Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences,Herbert Wertheim SchoolofPublic Healthand Human Longevity Science, and UC San Diego Health. J Cardiovasc Med (Hagerstown). Am J Physiol Gastrointest Liver Physiol. J Hepatol. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. J Clin Invest. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. Nature. 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HBO Special recorded in Las David has 2 jobs listed on their profile. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS. Hepatology. Recent advancement of molecular mechanisms of liver fibrosis. Proc Natl Acad Sci U S A. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. 2016 11; 64(5):1547-1558. Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial. Molecular and cellular biology of the small intestine. Gastroenterology. 2017 01; 65(1):78-88. New therapies for hepatic fibrosis. 2000 Aug; 119(2):446-60. 1979 Sep-Oct; 52(5):449-54. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. 2012 Jun 12; 109(24):9448-53. J Clin Invest. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. 1998 Sep; 13(S1):S39-S50. 1997 10; 273(4):G795-803. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. Toll-like receptors and adaptor molecules in liver disease: update. 2009 Jan; 49(1):6-8. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical J Biol Chem. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Migration of fibrocytes in fibrogenic liver injury. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. New Developments on the Treatment of Liver Fibrosis. J Hepatobiliary Pancreat Sci. Copyright The Regents of the University of California, Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Am J Physiol Gastrointest Liver Physiol. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. Cancer Res. Proc Natl Acad Sci U S A. 2013 Dec; 58(6):1930-40. Hepatology. The enzymatic defect in variegate prophyria. Am J Physiol. Dig Liver Dis. 2010 Jul-Aug; 19(4):311-20. J Biol Chem. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. Serum ?-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. 2019 11 05; 30(5):850-852. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. Hepatology. Identification of small molecule activators of cryptochrome. Clin Gastroenterol Hepatol. J Biol Chem. Hepatology. 2005 Jun; 42(6):850-9. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. The gut-liver axis and the intersection with the microbiome. Proc Natl Acad Sci U S A. Hepatology. J Biol Chem. 2011 Jan; 53(1):96-105. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. 1988 Apr 25; 263(12):5841-5. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. 2004 Apr; 18(6):720-2. Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T. NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Overexpression of endoglin modulates TGF-1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. 1999; 66:205-22. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. 2003 Sep; 285(3):G642-51. 2005 Sep 16; 335(1):87-96. He did not respond to inewsource s interview request. Zhang EE, Liu Y, Dentin R, Pongsawakul PY. 2003 May; 37(5):1043-55. Hepatology. J Gastroenterol Hepatol. HIV-1 infection and expression in human colonic cells: infection and expression in CD4+ and CD4- cell lines. 2002 Dec; 36(6):1498-508. J Stroke Cerebrovasc Dis. The InTeam is led by Dr. Ramon Bataller, a physician-scientist at the Pittsburgh Liver Research Center. 2000 Apr 21; 275(16):11814-23. 2020 11; 41:101039. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. 2000 Dec; 32(6):1255-64. 2020 Nov 03; 32(5):901. J Clin Gastroenterol. The renin-angiotensin-aldosterone system in cerebral small vessel disease. Licato LL, Keku TO, Wurzelmann JI, Murray SC, Woosley JT, Sandler RS. J Hepatol. Carethers will report directly to the chancellor and is part of the leadership team. 2009 Oct; 297(4):G726-34. We lose people all of the time. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, Were glad theres been a settlement. 2014 Jan; 59(1):19-20. Aliment Pharmacol Ther. Transplantation. 2019 Feb; 3(2):180-192. 1997 Nov; 113(5):1589-98. Clin Gastroenterol Hepatol. 2006 Apr; 290(4):G583-9. Am J Physiol. Gastroenterology. J Clin Immunol. Nat Immunol. 2009 Sep; 1(8-9):513-24. 2001 Apr; 120(5):1251-62. 2012 Jun; 10(6):575-80. Yang L, Bataller R, Dulyx J, Coffman TM, Gins P, Rippe RA. 2009 Jan 16; 378(3):348-53. Contribution of bone marrow-derived fibrocytes to liver fibrosis. 2007 May; 132(6):2272-5. Adv Second Messenger Phosphoprotein Res. 2014 Oct 28; 83(18):1653-60. J Immunol. Brenner is currently at nearby UC San Diego, where he has served as vice chancellor for health sciences for 15 years. J Clin Invest. Gastroenterology. 2018 12; 16(12):1974-1982.e7. 2004 Feb; 24(4):1758-68. Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. Exp Neurol. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. Fibrogenesis of parenchymal organs. 2012 Jun; 56(6):1283-92. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. Transplantation. Hepatology. Lackner JM, Jaccard J, Keefer L, Firth R, Carosella AM, Sitrin M. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Hepatology. Hepatol Res. Hepatology. Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F. 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