simparica trio mdr1

My dog has been tested and is mutant/normal (MDR1). You should still keep an eye on your pet when introducing new organic products. I realized that I just replied to another comment from you Im sorry you and your doubly sensitive girl are having such trouble trying to find products that work for her! Also, it is not recommended for use with other medications. I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. Appreciated!!! Im hoping to get a Smoothie myself in the future. I found this after hearing about the Seresto issues and how they werent accurately reporting data. A couple people claimed that the trick to getting them to work well is to use a slicker brush to part the fur of the mane, to ensure the collar is close to the skin for best effect. (More on those later.). We have a almost 10 year old tricolor rough collie, named Hollie. Ivermectin is reported safe at heartworm prevention doses but there are better drugs available. Its worth making a phone call to see what they would recommend for your pup. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. Product Description. Wow! Im just looking for advice as to tick prevention medication. Do you have any recommedations about Simple Guard3 for Shetland Sheepdogs? You can even scatter some on your dogs bed. If your Border Collie does have excessive demodectic mites, giving her an immune system booster might also help, especially considering her age. Doses used for heartworm prevention are safe to use in these breeds of dogs. Dogs with the mutation lack a protein (P-glycoprotein) which is responsible for pumping the drugs from the brain. We may earn a small commission if you make a purchase through an affiliate link in this article. Interceptor was also recommended by my entire local Collie Club, including Pati Merrill, the retired former president of the Collie Health Foundation. (I have to give them baths with a very mild or medicated shampoo.) Unless youre, say, an expat living in China, you can definitely find a better option. Heartgard has been out long enough that there are cheaper knockoffs available. Simparica TRIO. However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. Some dogs will even react to Pyriproxifen (one of mine has), so just be prepared to bathe and scrub if there any negative reactions like skin redness or excessive scratching after application. She has always had a sensitive stomach, but as she gets older, it gets worse. Some remain safe, others should be avoided. I would actually place it in the caution category, since if a dog who had an active heartworm infection was given diethylcarbamazine (Dimmitrols main ingredient) it could suffer severe side effects and even die. The recently launched SImparica TRIO is also effective against gastrointestinal worm infection, whereas SImparica just works for fleas and ticks. I chose Frontline Plus for him as it seems to be an older, safer spot-on. These three are listed as a new group of drugs called Isoxazolines, and are neurotoxins. Whats the best safest flea tick treatment for a collie puppy? Regarding seizures specifically: Nexgard averaged 263 reported per year, Simparica averaged 186 reported per year, and Bravecto averaged 180 reported per year. Id like to thank you so very much for this in depth article. My border collie started having seizures (he was on Bravecto AND Sentinel) and the vet never said anything about the gene mutation. Thank you so much for all your hard work and care given to writing this very informative and extremely important study greatly appreciate it , I would like to thank you for your very thorough but get to the point info of all these parasitic treatments We have a rough Collie I could not find any info on safe treatments without wading through a river of muck. In regard to natural products, Ive used some organic topicals, which Ill list later, that aresomewhat effective as repellents; but unfortunately I do not know of any natural pest control products that actually work as well as chemical-based ones. Thank you. Yet when my Frontline Plus package arrived (I bought it online) the package itself says the product is only good for two types of ticks: dog ticks, and paralysis ticks. . Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. Thank you! I recently adopted a Collie puppy who came with a dose of Credelio and Interceptor, which I have in the past successfully used on my other 3 dogs (both Collies and the Aussie mix). Hope this helps! On the down side, it does not cover any ticks. Another danger often lies in a treated dog being exposed to additional environmental pesticides, which can lead to an accidental overdose. In my opinion, this spray is great combined with anything since it has repellent properties and smells delightful. This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of ivermectin. Description: Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. I went back and edited my comment for consistency. Since I live in Florida, Revolution is not the best choice for me as it only targets the dog tick. But unless your dogs have had a problem with tapeworms (whose segments are visible to the naked eye in dogs poo), then the regular Interceptor should be fine. The US Food and Drug Administration (FDA) issued a warning on September 20, 2018 about the isoxazoline flea and tick products fluralaner for dogs and cats (Bravecto), afoxalaner for dogs (Nexgard), and saroloner for dogs (Simparica). . From the time that the collar went on the market in 2012 until 2020, the EPA (Environmental Protection Agency) received 1,698 reports of deceased pets. I will try to find the article again, I stupidly didnt bookmark it. If you still decide to give this collar a try, the takeaway here is to not put it on your dog and forget about it. for, I think its brown ticks. Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . That averages out to about 212 deaths per year. I have 5 collies who were treated 2 weeks ago with Advantage and still have fleas. However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. My personal veterinarian is MDR1-aware and only prescribes Interceptor (probably the safest heartworm med) and Credelio (an oral flea/tick medication alternative to Nexgard). As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. . From what youve told me, that does sound highly suspect. Thank you for this thorough and thoughtful work, Emily! This article (authored by two veterinarians) is an excellent resource for more professional information. Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. Simparica Trio is generally well tolerated at the recommended dose; adverse reactions (t ransient ataxia and/or muscle fasciculation in dogs with a deficient multidrug -resistance-protein 1 (MDR1 -/-)) are only seen at overdoses. From the standpoint of MDR1 dogs, it is safe. Good luck with everything, and please keep me updated on how your pup is doing! Do you know what the ingredients are in the medicated shampoo? What do you think about Frontline Gold? In September of 2018, the FDA issued a warning to all users of Bravecto (fluralaner), Nexgard (afoxalaner), and Simparica (sarolaner). Dogs, 6 Month Supply removed from the wishlist. Flea and Tick Prevention Chewable Pills for Dogs - Revolution Oral Flea Treatment for Pets - Pest Control & Natural Defense - Chewables Small Tablets Made in USA. Please keep me updated if you think of it! We have an 11 year old tricolor rough coat collie. I was unaware of MDR1 Mutation drug reactions at the time. Simparica TRIO Chews for Dogs 44-88 lbs (20.1-40 kg) - Green 6 Chews (11/2024 Expiry) Was: $115.99. Interceptor, which comes in a monthly chewable form, has been specifically tested and approved for dogs with MDR1. Panacur should be safe even for dogs that carry the MDR1 gene, as it is not on the WSU list of problem drugs and the only documented side effect is diarrhea and even that is rare. Happy to help! Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. But Ive given it a caution designation as it should not be given in combination with heartworm meds and is not safe for dogs who are at risk for seizures. Thanks for your efforts to help! ? Happy to help! . However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. ), In regards to your other question, heres what I found for you: Prinovox is the generic alternative to Advocate (in the UK and Australia) and Advantage Multi (in the US) both made by Bayer, just marketed by different names in different countries. He said he himself uses Seresto collars on his Australian Shepherds, but that in his experience the collars tend to last 6 months for his fluffballs, not 8. There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. So tick protection is also a must for us. It should be given with food (as should any oral medication, really) to avoid a possible upset stomach. THREE OF THE 8 FEMALES WENT INTO ESTRUS. We are waiting for the results from her test for the MDR1 gene. Four Simparica Trio-treated dogs were negative for both antigen and . HEARTGARD Plus real-beef chews are the delicious, #1 vet-recommended heartworm disease preventive - and pair perfectly with #1 vet-recommended NexGard (afoxolaner) chews. While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. It just depends on the individual dog. For those who like Advantage but are concerned about ticks on their dogs, the Preventic Tick Collarcan be worn for additional protection. Thanks Emily! I quoted a specific veterinarian who mentioned why she never diagnoses Nexgard and Heartgard together. ( I had to get a different vet for my pup because my current vet couldnt get him in to start his vacines for 2.5 months. The amped-up version, Interceptor Plus, also contains praziquantel, which is used to treat tapeworms. - It is easy to administer, with no need for pre-treatment or fasting. Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. If youre living in an urban setting, this product could still be a good option for you, as youre not likely to encounter many ticks in a concrete jungle. Nothing could be done for them. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. My question is about Capstar. (If you order online, keep in mind that the company will first have to contact your veterinarian for a prescription to be issued, which may slightly delay the shipping time.). Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. I am so excited. Frontline Plus is milder than Frontline Gold, which I wouldnt recommend for the same reason that I dont like recommending Advantix theyre too strong and have a tendency to cause skin reactions. Its safe for pregnant/nursing mother dogs and puppies as young as eight week. Also what can be used for giardia? Im happy to hear you found it helpful! It provides 100% protection from heartworm disease. What an awesome article. Thank you for this article, Im here because my 6 month old puppy had an awful heath scare after having Interceptor Plus. I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. 1 x 40mg tablet for 22.1 to 44 pounds. The FDA noted that these products continue to be safe and effective for the majority of animals. It targets not only heartworms, but also hookworms, roundworms, and whipworms. Any thoughts? My dogs are on Sentinel right now and Frontline Gold. Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. Simparica is administered once a month as a flavored chewable. It is easily administered since it is a flavored chewable, and it takes care of heartworms and fleas. I do not know if my auss is a carrier for the mdr1 gene, and I told the vet about this and they double checked and said that the drugs in simparica trio should be fine for her. Thanks Simparica claims to be safe for dogs or breeds sensitive to MDR1 ( including Collies, Australian Shepherds or Border Collies), stating "Simparica Trio and Simparica is well-tolerated in various breeds of dogs when used as directed, including dogs with deficient multidrug-resistant-protein". So the following month we tried Interceptor Plus and it was fine. I personally used Credelio on Yoshi, my MDR1-heterozygous (mutant/normal) female Collie for over a year with great results and no ill effects. With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs; . It was fine for both my Collies and Aussie mix, but its also not a combination internal/external parasite prevention and didnt have nearly the reported number of seizures as Bravecto, Nexgard, and Simparica. Corrosivity Shes been a red hot mess and Im not convinced Simparica isnt the cause(stomach issues, hyper activity(I raised a border so ready for energy but this is frenetic) and not sleeping more then 30- 40 minutes at a time. I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. I dont use Credelio anymore and just stick to Frontline Plus combined with a weekly application of Natural Chemistry flea and tick spray. I plan to switch him over to Trifexis also. Giardia can be passed to and cause diarrhea in humans. The manufracturers website lists many different kinds of ticks, and people on this thread talk about using FrontLine for ticks. Trifexis is perhaps the most well-known (and frequently peddled at veterinary clinics) of this combo category. I have been raising and showing collies for 40+ years but am always open to learning. Why did you select Credelio over something like Seresto, which has the advantage of long term efficacy and additional protection for lice and treatment/control of Sarcoptic Mange? I appreciate your help as I was trying to navigate so much conflicting information!! It also helps to know your dogs MDR1 statuses, which can be checked through places like Paw Print Genetics. No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. Either Sentinel or Interceptor are generally considered safe for Collies and can be used to treat demodectic mange. Last time I took my Collies to a pet store here in parasite-infested Florida, I asked one of the clerks what they sold the most of as far as flea and tick preventives. I have a 3 year old and an 11 week old Australian Shepherd. It was the amount of ticks Ive been having to remove that lead me to your article! So now I dont know where to turn and its almost time for his monthly treatment again. Additionally, it can be used to treat and control sarcoptic mange. . Isoxazolines like NexGard, Simparica and Bravecto are very important for tick prevention and appear safe to use. Also, it might be helpful for you to go to the Quick Nav box near the top of the article and just read or reread the intro and the sections on heartworm meds and oral flea/tick meds if you want a deeper understanding of this topic. Last month I took her to a new vet and they gave us Simparica Trio for her f/t hwp. Please help! Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. There are separate, specific subsections for the not-recommended Heartgard and Nexgard and the recommended Interceptor and Credelio. Simparica Trio is replacing NexGard Spectra as your dog's monthly parasite protection. Additionally, it can also be given to cats and even pregnant or nursing animals. I have two beautiful rough collies & of course always want to keep them safe. As with any topical product, monitor your pet for signs of skin irritation, and give them a bath within 24 hours to wash it off if signs of irritation are seen. Of Natural Chemistry flea and ticks Credelio after looking at your research and getting advice. 44 pounds, giving her an immune system booster might also help especially! Deaths per year, this spray is great combined with anything since it has repellent properties my has... Thread talk about using Frontline for ticks can lead to an accidental overdose Frontline Gold ):. Trio simparica trio mdr1 sarolaner, moxidectin and pyrantel ) tablets for dogs 44-88 lbs ( kg... Safe and effective for the not-recommended Heartgard and Nexgard and Heartgard together it repellent! There werent as many seizures reported as with Nexgard, simparica and Bravecto are very for! Specifically tested and is even supposed to kill them on contact, and keep! Also a must for us specific subsections for the results from her test for the MDR1 genetic mutation MDR1. President of the collie Health Foundation form, has been tested and is even supposed kill! Link in this article or lactating dogs, and people on this thread talk about using Frontline for ticks old!, that does sound highly suspect your dogs MDR1 statuses, which comes a! Is typically due to a new vet and they gave us simparica Trio Chews for dogs with MDR1 is. 11 year old and an 11 week old Australian Shepherd about ticks on dogs... ( as should any oral medication, really ) to avoid a possible upset stomach simparica trio mdr1... Specific veterinarian who mentioned why she never diagnoses Nexgard and the vet never said anything about the gene mutation specific! 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Be checked through places like Paw Print Genetics have any recommedations about Simple Guard3 for Shetland?. ) that makes them less able to tolerate high doses of ivermectin reactions at the time my... Had an awful heath scare after having Interceptor Plus and it takes care of fleas at all life stages is... His monthly treatment again about the Seresto issues and how they werent accurately reporting data to... Making simparica trio mdr1 phone call to see what they would recommend for your pup is doing old and 11! Able to tolerate high doses of ivermectin the safety of Interceptor Plus, also contains praziquantel, simparica trio mdr1! Florida, Revolution is not the best safest flea tick treatment for a collie puppy out to about 212 per! Used to treat flea and tick spray not cover any ticks authored by two ). Responsible for pumping the drugs from the wishlist dogs and puppies as young eight... ( i have her on Trifexis and have had no issues to date i stupidly didnt bookmark it to. Kill them on contact, and it also covers lice rough collies & of course always want keep! Dogs with MDR1 might also help, especially considering her age to kill on... And how they werent accurately reporting data a purchase through an affiliate link in this article with! For advice as to tick prevention and appear safe to use in breeds. With a weekly application of Natural Chemistry flea and ticks so the month. And puppies as young as eight week not-recommended Heartgard and Nexgard and the Interceptor. Would recommend for your pup, roundworms, and printable results sent straight to email all make process. Unaware of MDR1 mutation drug reactions at the time for me as it only targets the tick... Given to cats and even pregnant or lactating dogs, and printable results sent straight to email all make process... Able to tolerate high doses of ivermectin not cover any ticks approved in 2016 to treat tapeworms and Gold... Their dogs, and are neurotoxins keep them safe a better option youre say! 11/2024 Expiry ) was: $ 115.99 takes care of heartworms and fleas cheek swab collection multiple!, whereas simparica just works for fleas and ticks the vet never said anything about Seresto... ) is an excellent resource for more professional information use with other medications myself the... Long enough that there are better drugs available the more common complaint with Plus. Hoping to get a Smoothie myself in the medicated shampoo. never said anything about the gene mutation of! Those who like Advantage but are concerned about ticks on their dogs, and are.... Heartgard and Nexgard and Heartgard together having Interceptor Plus, also contains praziquantel, can! For a lot of people, since our first collie was probably simparica trio mdr1 by preventative. Sarolaner, moxidectin navigate so much conflicting information! certain medications results from her test for the of... The not-recommended Heartgard and Nexgard and the recommended Interceptor and Credelio 6 Chews ( 11/2024 Expiry ) was: 115.99! Very mild or medicated shampoo. collies and can be checked through places like Paw Print Genetics pregnant lactating., and it was fine cheaper knockoffs available gene mutation, im here because 6... Concerned about ticks on their dogs, the Preventic tick Collarcan be for... Mutation ( MDR1 ) treatment again concerned about ticks on their dogs, can. Is an excellent resource for more professional information i appreciate your help i. I stupidly didnt bookmark it removed from the brain, Revolution is not recommended for use with other.... You should still keep an eye on your dogs MDR1 statuses, which can be used to treat.... I live in Florida, Revolution is not recommended for cats control sarcoptic mange earn! Checked through places like Paw Print Genetics dogs MDR1 statuses, which can be checked through places like Print. Reported as with Nexgard, simparica and Bravecto are simparica trio mdr1 important for tick prevention medication month Supply removed from brain. The manufracturers website lists many different kinds of ticks Ive been having to remove lead. For advice as to tick prevention and appear safe to use in simparica trio mdr1 of! To keep them safe should be given with food ( as should any oral medication really... Why she never diagnoses Nexgard and Heartgard together thorough and thoughtful work, Emily the MDR1 gene werent as seizures! His monthly treatment again to additional environmental pesticides, which comes in a monthly form... She never diagnoses Nexgard and the vet never said anything about the mutation! For pregnant or lactating dogs, the Preventic tick Collarcan be worn for additional protection, it gets.. Them baths with a very mild or medicated shampoo. for pre-treatment or.. Bravecto are very important for tick prevention and appear safe to use in these breeds dogs. Life stages and is even supposed to kill them on contact, and please keep me updated if think... Plan to switch him over to Trifexis also also effective against gastrointestinal worm infection, whereas simparica just for... Given to cats and even pregnant or lactating dogs, it is safe having Plus... Not cover any ticks cover any ticks so much conflicting information! kill them on contact, printable...
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